TABLE 6.

Tyr, Trp, and His rotamers in TM barrels

		χ							Extension
AA	Rot	1	2	Soluble %	In (%)	Out (%)	Out-N (%)	Out-C (%)	Direction	Distance
Tyr	1	−60	90	74.8	5 (12)	16 (16)	10 (45)	6 (7)	N	−3.2
	2	180	90	15.3	12 (28)	79 (77)	6 (27)	73 (90)	C	5.0
	3	+60	90	5.9	26 (60)	8 (8)	6 (27)	2 (2)	N	−2.0
	Total				43	103	22	81
Trp	1	−60	120	55.2	0 (0)	5 (20)	5 (50)	0 (0)	N	−2.4
	2	−60	−120	10.9	1 (7)	3 (12)	1 (10)	2 (13)	N	−1.1
	3	180	−120	9.2	0 (0)	1 (4)	0 (0)	1 (7)	C	3.1
	4	180	120	9.1	1 (7)	6 (24)	0 (0)	6 (40)	C	3.0
	6	180	0	3.8	2 (13)	6 (24)	2 (20)	4 (27)	C	3.2
	7	+60	120	1.8	4 (27)	1 (4)	0 (0)	1 (7)	N	−0.4
	8	+60	−120	1.6	6 (40)	3 (12)	2 (20)	1 (7)	N	−1.5
	9	+60	0	0.1	1 (7)	0 (0)	0 (0)	0 (0)	N	−1.0
	Total				15	25	10	15
His	1	−60	−60	38.7	2 (20)	3 (25)	2 (33)	1 (17)	N	−1.4
	2	−60	+60	24.1	1 (10)	1 (8)	1 (17)	0 (0)	N	−1.8
	3	180	+60	11.0	1 (10)	3 (25)	0 (0)	3 (50)	C	2.4
	4	180	−60	10.7	2 (20)	3 (25)	1 (17)	2 (33)	C	2.5
	5	−60	180	8.9	0 (0)	1 (8)	1 (17)	0 (0)	N	−1.5
	7	+60	+60	2.1	3 (30)	0 (0)	0 (0)	0 (0)	N	−0.2
	8	+60	−60	1.2	1 (10)	1 (8)	1 (17)	0 (0)	N	−1.0
	Total				10	12	6	6