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. 2002 Sep 23;99(20):12512–12514. doi: 10.1073/pnas.212518099

Figure 1.

Figure 1

Eukaryotic mRNA decay mechanisms and enzymes. Two general mRNA decay pathways. Both pathways are initiated by deadenylation by the Ccr4/Pop2/Not complex or possibly by the alternative deadenylases, Pan2/Pan3 and PARN. Poly(A) tail shortening can lead to either 3′-5′ exonucleolytic digestion by the exosome or decapping by the Dcp1/Dcp2 complex. Decapping is followed by 5′-3′ exonuclease digestion by Xrn1. The residual cap structure resulting from exosome digestion is cleaved by the scavenger decapping enzyme DcpS.