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Cartoon of a T-cell membrane (top) adhering to an APC membrane (bottom). The T-cell membrane contains the T-cell receptor TCR (green) and the receptor LFA-1 (red). The APC membrane contains the corresponding ligands MHCp (green) and ICAM-1 (red). Both membranes contain repulsive glycoproteins (gray). Because of the different lengths of bound TCR/MHCp complexes, LFA-1/ICAM-1 complexes, and glycoproteins, the membrane phase separates into domains.
