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. 2004 Sep 17;87(6):3665–3678. doi: 10.1529/biophysj.104.045609

FIGURE 8.

FIGURE 8

TCR/MHCp ring occupation Y at various forces F = f · kBT/a as a function of time t for the same molecular concentrations as in Figs. 3 and 7. A ring occupation Y = 100% corresponds to fully closed peripheral ring of TCR/MHCp complexes; smaller percentages of Y correspond to partial occupations of the peripheral ring with distances r > 35a from the center of the contact zone. T-cell like pattern evolution with intermediate values of Y ≳ 80% (inverted synapse) and final values of Y ≃ 0% (mature synapse) are obtained for forces between F = 0.01 kBT/a and F = 0.1 kBT/a (see also Fig. 7). Larger forces prevent the formation of an intermediate peripheral TCR/MHCp ring, whereas smaller forces do not lead to a final central TCR/MHCp cluster. The data points represent averages over 24 independent Monte Carlo runs for each force.