TABLE 2.
Relevant structural parameters for HA5 and HA7 in POPC
Peptide | Hcalc*(%) | HCD†(%) | HNMR‡(%) | Tilt angle(°) | Thickness§ (Å) |
---|---|---|---|---|---|
HA5 | 71.0 | 33 | 66.0 | 32.7 | 31.7 |
HA7 | 47.6 | - | 40.2 | 31.0 | 26.9 |
Helical content (in % over all residues) calculated from the last 2ns of each trajectory.
Helical content measured from CD experiments in POPC.
Helical content calculated from the PDB structures in SDS micelles.
Membrane thickness measured as the average difference in the Y coordinates of the phosphor atoms of the upper and lower leaflets (membrane is in XZ plane).