TABLE 2.

Subsets of directionally coupled metabolites in glycolysis

No.	Subset	Range of conservation ratios	Visual interpretation
1	1,3BPG	Reference	1,3BPG → 2PG
	2PG	[0.5, ∞)
2	AMP	Reference	AMP → ADP
	ADP	[0.5, ∞)
3	ATP	Reference	ATP → ADP
	ADP	[0.5, ∞)
4	DHAP	Reference	DHAP → F6P
	F6P	[1, ∞)
5	Glu	Reference	Glu → F6P
	F6P	[0.5, ∞)
6	H2O	Reference	H2O → 2PG
	2PG	[1, ∞)
7	PEP	Reference
	1,3BPG	[1, ∞)	1,3BPG ← PEP → 2PG
	2PG	[1, ∞)
8	PYR	Reference	PYR → 2PG
	2PG	[1, ∞)
9	Pi	Reference
	1,3BPG	[1, ∞)	1,3BPG ← Pi → 2PG
	2PG	[1, ∞)