Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanistic pathway of cytosine modifications in DNA. The unmodified nucleoside 2-dC is converted to 5-mdC through enzymatic methylation catalyzed by DNA methyltransferases (DNMTs). 5-mdC is further transformed to 5-hmdC by Ten-eleven translocation (TET) enzymes via hydroxymethylation [6].
