TABLE 2.
PC/SM/chol (1:1:1) | PC/chol (2:1) | PS/PE/chol (1:1:1) | |
---|---|---|---|
Quinidine | 68 ± 7 | 112 ± 9 | 717 ± 28 |
Amprenavir | 148 ± 12 | 205 ± 22 | 228 ± 17 |
Loperamide | 671 ± 23 | 1045 ± 122 | 3138 ± 624 |
Extruded 0.1 μm LUV of the prescribed lipid composition at 10 mM total lipid concentration was incubated with drug at 10 μM concentration for 6 h. Partition coefficients (mol drug per liter of LUV bilayer/mol drug per liter buffer) were calculated as described in Materials and Methods. Preliminary studies established that equilibrium was reached under these conditions. Mean ± SD of four replicates for each drug are shown.