TABLE 2.

Drug equilibrium partition coefficients (v/v) with LUV

	PC/SM/chol (1:1:1)	PC/chol (2:1)	PS/PE/chol (1:1:1)
Quinidine	68 ± 7	112 ± 9	717 ± 28
Amprenavir	148 ± 12	205 ± 22	228 ± 17
Loperamide	671 ± 23	1045 ± 122	3138 ± 624

Extruded 0.1 μm LUV of the prescribed lipid composition at 10 mM total lipid concentration was incubated with drug at 10 μM concentration for 6 h. Partition coefficients (mol drug per liter of LUV bilayer/mol drug per liter buffer) were calculated as described in Materials and Methods. Preliminary studies established that equilibrium was reached under these conditions. Mean ± SD of four replicates for each drug are shown.