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. 2026 Mar 23;17:1707493. doi: 10.3389/fimmu.2026.1707493

Figure 2.

Panel A shows a principal component analysis (PCA) plot comparing microbial communities between Sham (blue) and CLP (red) groups, with clear separation between groups. Panel B contains a box plot of the microbial dysbiosis index (MDI), indicating significantly higher dysbiosis in CLP compared to Sham. Panel C shows a clustered heatmap of metabolic pathway abundances in Sham versus CLP groups, with category legends annotated beside the heatmap. Panel D displays a hierarchical heatmap of the relative abundances of key bacterial genera in Sham and CLP groups, with genus names labeled. Panel E presents Wilcoxon rank-sum test results as horizontal bar plots for genus-level bacterial proportions, showing proportions, differences, 95 percent confidence intervals, effect sizes, and log2 fold-changes between Sham and CLP groups.

Intestinal Blautia is involved in the progression of SI-ALI in rats. (A) Principal component analysis (PCA) of gut microbiome in Sham and CLP rats at the OTU level (fecal samples were collected 72 hours after CLP surgery). (B) Comparative analysis of MDI between sham controls and the CLP group. (C) Functional analysis of intestinal flora in CLP-induced ALI rats and sham-operated group based on PICRUSt2. (D) Relative abundance of gut microbial species in sham controls and CLP Models (genus level). (E) Differences in intestinal microbiota composition at the genus level between sham-operated and CLP-induced SI-ALI rats. * P<0.05.