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. 2026 Mar 23;17:1707493. doi: 10.3389/fimmu.2026.1707493

Figure 5.

Panel A shows a schematic timeline of a mouse experimental protocol involving gavage, surgery, and harvest. Panel B features a survival curve comparing three groups: Sham, CLP, and CLP+IAA. Panel C presents lung histology images from each group and associated bar graphs quantifying histological scores and lung weight-to-body weight ratios. Panels E, G, I, and K display representative flow cytometry plots for T cell subpopulations in each group. Panels F, H, J, and L depict corresponding bar graphs with statistical comparisons of CD8+ and CD4+ T cell percentages, granzyme B, and interferon-gamma expression. Statistical significance is indicated with asterisks throughout.

IAA Attenuates SI-ALI Through Enhanced CD8+ T Cell Effector Functions. (A) Experimental grouping and treatment flowchart for rats. (B) Kaplan-Meier survival analysis: Sham-operated, CLP-Induced SI-ALI, and IAA-Pretreated rats. (C) Representative H&E-stained rat lung sections and histological scores of Sham-operated, CLP, and IAA-Pretreated cohorts. (D) Comparison of the Lung Wet/Dry Weight Ratio of rats in each group. (E–H) Peripheral blood T cell frequency and cytokine production: CD3+CD8+ populations, CD3+CD4+ populations, IFN-γ+CD8+ subsets, and Granzyme B+CD8+ subsets in Sham-operated, CLP group, and IAA-Pretreated CLP Groups. (I-L) Splenic T cell frequency and effector function:CD3+CD8+ populations, CD3+CD4+ populations, IFN-γ+CD8+ subsets, and Granzyme B+CD8+ subsets in Sham-operated, CLP group, and IAA-Pretreated CLP Groups. * P<0.05; ** P<0.01; *** p<0.001; **** p<0.0001.