Figure 2.
Effect of synthetic alloferon 1 on the natural killer activity of mouse spleenocytes (A) and human lymphocytes (B). The human lymphocytes, the mouse spleenocytes, and the [3H]uridine labeled K562 cells were coincubated in the absence or presence of alloferon 1 at various concentrations. The cytotoxicity indices (M ± SE) were calculated for each concentration as described by Trinchieri (10) based on 18 or 6 assays of mouse splenocyte or human lymphocyte activity, respectively. Human lymphocyte responsiveness was also compared with response to IFN-α 2b (▴).