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A model for the noncatalytic seeded polymerization. This model supposes that the various glycosylated forms have different ability to go through the coil-to-β (or α-to-β) structural transition and fibrillization. The fibrillogenesis process can be homogeneously seeded, or heterogeneously seeded by the nuclei provided from the external environment or formed because of aberrant glycosylation.
