FIGURE 2.

Filament spacing, calculated from the 1.1 equatorial x-ray diffraction pattern (d₁₁) from skinned fiber bundles of Des+/+ (open symbols) and Des−/− (solid symbols) psoas (A and B) and soleus (C and D) muscle preparations. Circles show data from relaxed fibers and squares from fibers in rigor. The spacing of the relaxed Des−/− soleus muscle (circles in C) was significantly larger compared to the Des+/+ group (ANOVA, p = 0.001). Panels B and D show values expressed relative to the spacing at 0% dextran. The relative spacing of Des−/− soleus muscle fibers in rigor at 8% dextran (squares in D) was significantly smaller than that of the corresponding Des+/+ group (p < 0.05, Student's t-test), n = 6–8.