FIGURE 5.

Stereo representation of the minor-groove binding ellipsoids obtained by global density refinement of the water-binding sites from high resolution B-DNA structures on a 6-bp fragment of a polyamide drug-DNA complex, bdd002 (Kielkopf et al., 1998b). The proton donor and acceptor atoms on the drug are denoted by small magenta spheres. The ellipsoids of donor ligands in the vicinity of proton acceptor atoms on the bases are illustrated in blue and those of acceptor ligands in contact with proton donors on the base are shown in red.