FIGURE 4.

Lamellipodial stability correlates with directional persistence in CHO-EGFR migration. (A) Fn coating concentration does not affect the average velocity of membrane protrusion. The average slope of ascending kymograph membrane waves defines protrusion velocity. ANOVA: p = 0.86. (B) Protrusion stability increases with Fn concentration in the presence of EGF. Stability represents the time elapsed between the beginning of a single protrusion wave and its spatial peak. Nonoverlapping 95% confidence intervals are indicated by asterisks. ANOVA: p = 0.03.