TABLE 1.

Simulation parameters

Parameter	Definition	Value (reference)
	RBC diameter	8.4 μm (Skalak and Chien, 1987)
	RBC thickness	1.98 μm (Skalak and Chien, 1987)
Rc	Disk radius	4.5 μm (Skalak and Chien, 1987)
λ	Equilibrium bond length	20 nm (Chang and Hammer, 1996)
kf	Forward reaction rate	85 s−1 (Chang et al., 2000)
kr0	Reverse reaction rate	1·10−2 s−1 (Chang and Hammer, 1996)
σ	Spring constant	2·10−3 N/m (Chang and Hammer, 1996)
σ*	Transition state spring constant	1·10−3 N/m (Chang and Hammer, 1996)
T	Temperature	310 K (Chang and Hammer, 1996)
ν	Plasma kinematic viscosity	1.2·10−6 m2/s (Skalak and Chien, 1987)
uL	Mean inlet velocity	1000 μm/s (Schmid-Schobein et al., 1980)
ρc	Disk density	1070 Kg/m3 (Skalak and Chien, 1987)
ρd	RBC density	1098 Kg/m3 (Skalak and Chien, 1987)
ρf	Fluid density	1000 Kg/m3 (Skalak and Chien, 1987)
Hc	Critical height	40 nm (Chang et al., 2000)
D	Vessel diameter	20–40 μm (Skalak and Chien, 1987)
Re	Reynolds number (uLD/ν)	1.667·10−2–3.333·10−2
NL	Ligand density	47/μm2 (Chang and Hammer, 1996) (600 ligands along the cylinder peripheral circumference located every 0.45 μm)