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Overall effects of IHP and Cl− on L35-induced perturbations in COHbA
| Domains | Cl− | Effectors IHP | IHP+Cl− |
|---|---|---|---|
| Intrinsic fluorescence/α1β2 interface | Reduced | Enhanced | Reduced |
| Extrinsic HPT fluorescence/central cavity | Reduced | Enhanced | Reduced |
| UV CD 280-nm region/α1β2 interface | Reduced | Negated | Negated |
| Soret CD/heme environment | Reduced intensity (shift is negated) | Enhanced | Reduced |
Conditions: 1.0 g % COHbA, 50 mM HEPES, pH 6.35.
