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. 2002 Sep 13;99(20):12715–12720. doi: 10.1073/pnas.192463699

Figure 1.

Figure 1

(A) Outline of the progression of advanced metabolites in Taxol biosynthesis illustrating the acetylation of 10-deacetylbaccatin III to baccatin III by 10-deacetylbaccatin III O-acetyltransferase (a), the transfer of an aminophenylpropanoyl group to C-13 of baccatin III by an O-(3-amino-3-phenylpropanoyl)transferase (b), and the benzamidation and C-2′ hydroxylation of the side chain by N-debenzoyltaxol N-benzoyltransferase and a taxoid side chain hydroxylase (c). (B) Synthetic phenylpropanoyl-CoA esters used to assess substrate specificity of the O-(3-amino-3-phenylpropanoyl)transferase.