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. 2002 Sep 17;99(20):12727–12732. doi: 10.1073/pnas.202236699

Figure 5.

Figure 5

A two-step model for NC2 as a repressor of basal transcription and stimulator of activated transcription. NC2 stimulates the binding of TBP to DNA in the first step, yet its continued presence inhibits subsequent recruitment of TFIIA and TFIIB. Activators then counteract NC2 either directly or through co-activator intermediates, resulting in greater net stimulation by the combination of NC2 and activator due to the enhanced binding of TBP in the initial step. Activators can either physically remove NC2 from the TBP complex as shown, or inactivate its repression activity while allowing NC2 to remain bound to TBP.