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Schematic illustration of the proposed model for transient and repetitive depolarizations. (a) Proton pumps in the electron transfer chain translocate protons from the matrix to the intermembrane space. (b) The pH beneath the inner membrane is increased by proton pumping. (c) Opening of a pH sensitive and proton conductive channel is induced by the increase in the pH. (d) Reentry of protons through the channel decreases the pH, resulting in closing of the channel.
