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. 2005 Jan 14;88(4):2369–2383. doi: 10.1529/biophysj.104.053975

FIGURE 9.

FIGURE 9

Effect of strong parameter variations on oscillations. Each point represents a simulation where one parameter has been doubled or halved, keeping the other parameters constant. Amplitude and period are plotted relative to the amplitude and the period of the control. Measured amplitude is the amplitude of total FRQ oscillation. (solid triangle, δRNA; solid circle, θ; solid square, δFRQ; open triangle, ρWCC; open square, ρFRQ; open circle, β; open diamond, δWCC; and × symbol, other parameters.) (A) One-loop model (parameters of Fig. 3). (B) One-loop model (with δFRQ = 0.25 h−1, ρFRQ = 20 mol h−1, θ = 0.23 h−1, and α = 4 mol−1 h−1, with other parameters the same as Fig. 3). (C) First two-loop model (parameters of Fig. 5). Five parameters destroy oscillations. (D) Second two-loop model (parameters of Fig. 6).