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Direct visualization of lytic action of Aβ 1–42 peptide. Confocal microscopy of POPC (top) and POPC/SM/Chol (1:1:1 molar ratio, bottom) GUVs, filled with Alexa488-Dextran (green) and Alexa546-Maleimide (red), exposed to Aβ 1–42 7.5 μM. Effect of lipid-peptide interaction from the time, 0 s: injection of the peptide. Arrows indicate the differential leakage of the fluorophores.
