Figure 1.

The structure of the Hcp protein in the T6SS-4

(A) Sequence alignment of Hcp-4 of representative B. pseudomallei members, including CAH37616.1, CP038806.1, WP_041195571.1, WP_050043205.1, WP_038765868.1, WP_004529722.1, CAJ4793009.1 and WP_053565664.1 performed using MEGA 7.0. Differential residues are boxed in red and highlighted on a blank background and as red letters, respectively.

(B) Monomer structure of the Hcp protein.

(C) Analysis of the interactions between Hcp protein monomers and the key amino acid sites for these interactions is shown.

(D) Six polymer structure of the Hcp protein.