TABLE 1.

Parameters measured by QCM-D for the deposition of vesicles with varying lipid composition

Lipid ratio									Vesicle deposition pathway	Stability of vesicles at low coverage
DOTAP	DOPC	DOPS	[Ca](mM)	Δfmin(Hz)	ΔDmax(10−6)	Δffin(Hz)	ΔDfin(10−6)	tSLB(min)
1	–	–	0*	–	0.5	−25	0.2	12	SLB	Fast rupture†
1	4	–	0*	−35	2.7	−27	0.8	3	SLB	No rupture, no desorption
–	1	–	0*	−103	10.0	–	–	–	SVL	No rupture, slow desorption
	9	1	0*	−13	2.0	–	–	–	SVL	–
–	4	1	0*	0	0	–	–	–	No adsorption	–
1	–	–	2	–	0.3	−24	0.2	10	SLB	Fast rupture†
1	4	–	2	−32	1.8	−26.5	0.5	3	SLB	No rupture, no desorption
–	1	–	2	−50	4.0	−25	0	5	SLB	No rupture, no desorption
–	9	1	2	−50	2.6	−25	0	3.3	SLB	–
–	4	1	2	−45	2.5	−26	0.2	3.3	SLB	Slow rupture‡
–	2	1	2	−34	1.7	−25.5	0.2	5	SLB	Slow rupture‡
–	1	1	2	−36	1.5	−25.5	0.2	1.3	SLB	Slow rupture‡
–	1	2	2	−34	1.5	−25.5	0.2	2	SLB	Slow rupture‡
–	1	4	2	−32	1.0	−26	0.2	1.3	SLB	Slow rupture‡

^*Measured in the presence of 2 mM EDTA.

^†Isolated vesicles rupture within seconds or less after adsorption.

^‡Isolated vesicles rupture within minutes or hours after adsorption.