Figure 6.

Hormonal levels. Each point corresponds to a single mouse. (Upper) Results of progesterone and estradiol assays in Afp^{tm1Ibmm/tm1Ibmm} mutant females and controls. Assays were performed on serum from different batches of females maintained for at least 6 weeks in three different cages (A, B, C). Note the lack of progesterone in the mutant mice; the difference with the control mice is significant (P = 0.05). (Lower) Results of gonadotropin (LH and FSH) measurements in wild-type and Afp^{tm1Ibmm/tm1Ibmm} mutant females ovarectomized (OV: first two series) or not ovarectomized (last two series). The difference in the LH levels is significant (P = 0.01), whereas that in the FSH levels is not (P = 0.16).