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. 2026 Mar 12;14(4):e01915-25. doi: 10.1128/spectrum.01915-25

Fig 2.

RNA-seq analysis of CD64+ neutrophils revealing gene expression differences between tuberculosis states. Volcano plots show DEGs across ATB, LTBI and HC groups. Venn diagram quantifies overlaps while heatmap displays expression patterns by condition.

Analysis of RNA-seq in CD64+ neutrophils from ATB, LTBI, and HC. (A) Volcano plots of DEGs for three kinds of comparison: x axis, log2 fold change of ATB compared with HC; y axis, −log10 of P value; red dots represent upregulated DEGs, and blue dots represent downregulated DEGs. Marked DEGs refer to the most significant DEGs for comparisons between ATB vs HC, ATB vs LTBI, and LTBI vs HC. (B) The number of DEGs covers comparisons among these three groups of samples. (C) Hierarchical clustering heatmap of DEGs in all samples. Rows represent genes, and columns represent samples. Relative levels of gene expression are displayed by a color scale, with red or yellow indicating high expression and blue indicating low expression.