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. 2026 Mar 12;14(4):e01915-25. doi: 10.1128/spectrum.01915-25

Fig 4.

Gene expression analysis identifies GBP5, MYL12A, STAT1, EIF1, and SRSF5 as key markers differentiating ATB from other groups. Statistical tests and feature importance ranking confirm these genes provide effective diagnostic discrimination.

Statistical analysis of qPCR data and feature-importance ranking for the 20 selected genes. (A) Statistical comparison of qPCR results for the 20 genes across groups, analyzed using the Kruskal-Wallis test. (B) Analysis of feature importance and model intercept for the 20 genes, highlighting GBP5, MYL12A, STAT1, EIF1, and SRSF5 as the most important features. Among these genes, GBP5, MYL12A, EIF1, and SRSF5 were selected via LASSO regression modeling. (C) The combined expression levels of these genes demonstrated the highest discriminative ability between ATB and other groups, as assessed by the model. This figure provides a comprehensive overview of gene expression patterns and their relevance in distinguishing ATB from control groups.