Skip to main content
. 2026 Mar 12;14(4):e01915-25. doi: 10.1128/spectrum.01915-25

Fig 5.

ROC curves demonstrate Neu-TB signature diagnostic performance for active tuberculosis with AUC values >0.95 across cohorts. Bar charts show positive predictive values for various TB sample types compared to HC, LTBI, and NTB controls.

Evaluation of the 4-gene neu-TB signature as a diagnostic marker for active tuberculosis (ATB). (A) Receiver operating characteristic (ROC) curve analysis and corresponding areas under the curve (AUC) with 95% confidence intervals (CI) demonstrating this signature’s ability to distinguish active TB from other groups (HC, LTBI, HC+LTBI, NTB). (B) Positive predictive values across sample types, highlighting the neu-TB signature’s specificity and performance in differentiating ATB from other conditions.