Table 3. Association between baseline eGFR and cancer mortality (in-trial and post-trial combined).
| eGFR (mL/min/1.73 m2) – HR (95% CI), p | |||||
|---|---|---|---|---|---|
| ≥ 90 | 60 – 89.9 | 45 – 59.9 | < 45 | Test for trend (p) | |
| Cancer mortality | |||||
| Unadjusted | 1.00 (ref) | 0.98 (0.89 – 1.08) | 1.27 (1.11 – 1.45) | 1.88 (1.55 – 2.28) | < 0.001 |
| Adjusted* | 1.00 (ref) | 0.91 (0.81 – 1.02) | 1.09 (0.93 – 1.28) | 1.54 (1.22 – 1.94) | 0.004 |
| Prostate | |||||
| Unadjusted | 1.00 (ref) | 1.12 (0.78 – 1.61) | 2.08 (1.33 – 3.27) | 3.01 (1.54 – 5.87) | < 0.001 |
| Adjusted* | 1.00 (ref) | 1.07 (0.68 – 1.66) | 1.70 (0.98 – 2.95) | 1.83 (0.81 – 4.13) | 0.028 |
| Lung | |||||
| Unadjusted | 1.00 (ref) | 0.93 (0.79 – 1.11) | 1.20 (0.95 – 1.52) | 1.34 (0.91 – 1.98) | 0.082 |
| Adjusted* | 1.00 (ref) | 0.88 (0.71 – 1.09) | 1.09 (0.82 – 1.46) | 1.07 (0.66 – 1.73) | 0.584 |
| Colon | |||||
| Unadjusted | 1.00 (ref) | 1.12 (0.82 – 1.54) | 1.21 (0.78 – 1.88) | 2.15 (1.17 – 3.94) | 0.048 |
| Adjusted* | 1.00 (ref) | 1.29 (0.87 – 1.93) | 0.90 (0.49 – 1.65) | 2.28 (1.12 – 4.62) | 0.238 |
| Breast | |||||
| Unadjusted | 1.00 (ref) | 0.84 (0.53 – 1.33) | 1.38 (0.79 – 2.42) | 1.84 (0.81 – 4.21) | 0.113 |
| Adjusted** | 1.00 (ref) | 0.66 (0.39 – 1.13) | 1.14 (0.58 – 2.23) | 1.22 (0.45 – 3.35) | 0.572 |
| Urinary-tract | |||||
| Unadjusted | 1.00 (ref) | 1.17 (0.73 – 1.90) | 1.65 (0.89 – 3.06) | 3.99 (1.90 – 8.38) | 0.001 |
| Adjusted* | 1.00 (ref) | 0.99 (0.53 – 1.85) | 1.54 (0.72 – 3.32) | 2.95 (1.14 – 7.65) | 0.023 |
| Hematopoietic | |||||
| Unadjusted | 1.00 (ref) | 1.22 (0.85 – 1.77) | 1.62 (1.01 – 2.61) | 1.39 (0.59 – 3.30) | 0.066 |
| Adjusted* | 1.00 (ref) | 1.05 (0.65 – 1.70) | 1.67 (0.92 – 3.01) | 1.10 (0.37 – 3.24) | 0.179 |
| Other | |||||
| Unadjusted | 1.00 (ref) | 0.91 (0.78 – 1.08) | 1.09 (0.86 – 1.36) | 2.01 (1.47 – 2.75) | 0.005 |
| Adjusted* | 1.00 (ref) | 0.84 (0.69 – 1.03) | 0.88 (0.66 – 1.17) | 1.70 (1.17 – 2.46) | 0.259 |
*Adjusted for age, gender (except for prostate cancer), race, ethnicity, smoking status, diabetes, history of coronary heart disease, body mass index, systolic and diastolic blood pressure, total cholesterol, glucose, aspirin use, and antihypertensive treatment arm. **Adjusted for age, race, ethnicity, smoking status, diabetes, history of coronary heart disease, body mass index, systolic and diastolic blood pressure, total cholesterol, glucose, history of estrogen therapy, aspirin use, and antihypertensive treatment arm.