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. 2026 Mar 24;17:1784546. doi: 10.3389/fimmu.2026.1784546

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Copyright © 2026 Iacovelli, Sanjabi, Monemi, Amitai, Decalf, Moussion, Liao, Rao, Getz and Mancuso.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Grouped line charts show cell count (cells per milliliter) versus time (days) for various dendritic and monocyte cell subsets after single and multiple ascending doses of study medication. Panels A–D display data for five single dose groups while panels E–H show two multiple dose groups, each labeled for cell subset and dose regimen. All graphs indicate a dose-dependent increase in cell counts, peaking around day twenty-two, followed by a gradual decline. Error bars represent variability among data points. — Profiles of dose-dependent expansion and maintenance of (A, E) cDC1, (B, F) cDC2, (C, G) pDC, and (D, H) CD14+ monocytes following RO7497987 administration. Data shown as median with upper and lower quartiles.