Table 1.
Healthy participant demographics.
| Cohort | SAD1 0.7 mga |
SAD2 2.1 mg |
SAD3 7.0 mg |
SAD4 21 mg |
SAD5 70 mg |
MAD1 7.0 mg |
MAD2 21 mg |
|---|---|---|---|---|---|---|---|
| Participants treated | 6 | 7 (1 participant replaced due to dose error) | 6 | 6 | 7 (1 participant replaced after unrelated AE) | 6 | 6 |
| Number of doses | 1 | 1 | 1 | 1 | 1 | 2 (q 21d) | 2 (q 21d) |
| Age in years, median (range) | 37 (25-60) | 52 (25-60) | 46 (28-61) | 49 (24-64) | 49 (31-62) | 38 (35-65) | 42 (22-65) |
| Sex | 2M, 4F | 5M (1 replaced), 2F | 3M, 3F | 3M, 3F | 4M, 3F (1 replaced) | 5M, 1F | 1M, 5F |
| Race | |||||||
| Black/African American | 1 | 0 | 3 | 3 | 3 | 1 | 0 |
| White | 5 | 4 | 2 | 2 | 4 | 5 | 5 |
| Hispanic/Latino | 0 | 3 | 1 | 1 | 0 | 0 | 1 |
a
One participant was dosed 0.674 mg in error.