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. 2005 Apr 1;88(6):3991–3999. doi: 10.1529/biophysj.105.059352

FIGURE 3.

FIGURE 3

Steady-state inactivation of Nav1.5 wild-type and Nav1.5-S1759W. Currents were evoked by a 5-ms test pulse to +30 mV for (A) Nav1.5 wild-type and (B) Nav1.5-S1759W. Test pulses were preceded by 100-ms conditioning pulses, increased in 5-mV increments between −160 mV and −15 mV. (C) Normalized Na+ current availability (h∞) of Nav1.5 wild-type was plotted as a function of the conditioning voltage. Data were fitted with the Boltzmann function. The average midpoint (h0.5) and slope factor (kh) for the wild-type solution (○, n = 5) were −86.0 ± 1.2 mV and 7.4 ± 0.2 mV, respectively, and −94.9 ± 1.2 mV and 7.6 ± 0.2 mV for Nav1.5-S1759K (•, n = 5). Holding potential was set at −140 mV.