Figure 2.

(a) Thorax of a 24-week-old Zmpste24^−/− mouse. Fibrotic lesions surrounding broken ribs are indicated by arrows. (b) Radiograph of a Zmpste24^−/− mouse, revealing callus formation surrounding rib fractures (arrows). (c) Surface rendering of a μCT scan of the lower thoracic spine of a Zmpste24^−/− mouse. Callus is visible at the tips of several ribs near the costovertebral joints (arrowheads). (d) Maximal intensity projection from a μCT scan of the lower thoracic spine of a Zmpste24^−/− mouse, revealing multiple rib fractures (arrowheads). (e and f) Hematoxylin- and eosin-stained sections of rib fractures (arrows) and surrounding fibrosis (arrowheads). (g) Avulsion of a fragment of bone (arrowhead) from the cortex of the humerus. (h) Fracture of the mandible with fibrosis between bone fragments (arrowhead).