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. 2002 Sep 23;99(20):13079–13084. doi: 10.1073/pnas.182425299

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Copyright © 2002, The National Academy of Sciences

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CDI analysis of Tg(MoPrP,Q167R) mice. (a) Calibration curve performed on brain extracts of inoculated FVB mice. The europium-labeled HuM-D13 Fab was used for the detection of PrP. (b) CDI analysis of various brain homogenates. None, uninoculated wt FVB mice; 1 and 2, two prion-inoculated Tg(MoPrP,Q167R)Prnp^0/0 mice killed after 550 days; 3 and 4, two uninoculated Tg(MoPrP,Q167R)Prnp^0/0 mice killed after 420 days; 5 and 6, prion-inoculated FVB/Prnp^0/0 mice killed after 420 days; 7 and 8, prion-inoculated Tg(MoPrP,Q167R)Prnp^+/+ mice killed after 300 days; 9, an uninoculated Tg(MoPrP,Q167R)Prnp^+/+ mouse killed after 150 days. Data points and bars are average ± SEM obtained from three independent measurements.