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Stimulation of ICl,swell by PP2 requires cell swelling. I-V relationships in 1T and after exposure to 10 μM PP2 in 1T solution for 10 min are shown. Inset: families of PP2-induced difference currents in 1T solution. PP2 did not alter the outwardly rectifying background Cl− current attributed at least in part to ICl,swell under isosmotic conditions. Note the change in scale of I-V relationship compared with previous figures.
