Figure 3.

Time course of hyponatremia-induced brain edema. (a) Average ADC values in brain were normalized to the mean of baseline values. The arrow denotes i.p. injection of distilled water and 8-deamino-arginine vasopressin (water intoxication). Note that the gradual decline in ADC occurred in both experimental groups, indicating an increase in the size of the intracellular compartment. After 35 min, an abrupt, rapid decline in ADC occurred in the G178 control mice (○, broken line). After 52.5 min, a similar decline occurred in dystrophin-null mice (■, solid line). *, P < 0.05 (Student's t test). Data are presented as mean ± SE. (b) Survival profile for G178 control mice and dystrophin-null mice.