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. 2026 Apr 8;12(15):eaec4368. doi: 10.1126/sciadv.aec4368

Fig. 6. SLC13A2-mediated histone acetylation promotes transcriptional activation of key TFs.

Fig. 6.

(A) Metagene and heatmap analyses showing the distribution of acetylated lysine (Acetyl-Lys) peaks around TSS (±2 kb) from ChIP-seq of Acetyl-Lys in SLC13A2-OE Hepa1-6 cells. (B) Circular chord diagram displaying GO enrichment of DEGs categorized by functional terms. ATPase, adenosine triphosphatase. (C) Bar plots of GO enrichment analysis for up-regulated (orange) and down-regulated (blue) genes from RNA-seq of SLC13A2-OE mice. (D) Representative IGV tracks showing ChIP-seq (Acetyl-Lys) signals in SLC13A2-OE Hepa1-6 cells and RNA-seq signals from liver tumor tissues of SLC13A2-OE mice at selected loci (Igfbp6 and Apoa2). (E) IGV tracks of Acetyl-Lys ChIP-seq signals at Cebpa, Tcf21, and Bhlhe41 loci, showing increased acetylation. (F) Public ChIP-seq tracks (H3K9ac, H3K27ac, and H4K12ac) from H1 human embryonic stem cells and HepG2 cells (ENCODE database) showing promoter acetylation at Cebpa, Tcf21, and Bhlhe41. (G) GO enrichment analysis of down-regulated DEGs from RNA-seq that are potential downstream targets of TFs Cebpa, Tcf21, and Bhlhe41. (H) Heatmap of representative downstream genes of Cebpa, Tcf21, and Bhlhe41 in SLC13A2-OE tumor tissues.