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. 2026 Apr 8;12(15):eaec4368. doi: 10.1126/sciadv.aec4368

Fig. 7. SLC13A2 overexpression suppresses tumor growth in PDX model.

Fig. 7.

(A) hSLC13A2 overexpression efficiency in PDX HCC tissues (n = 4). (B) PDX HCC morphology upon dissection. Scale bar, 10 mm. (C and D) Body weight and tumor weight in the two groups (n = 4). (E) Tumor volume in the two groups (n = 4). (F) Representative images of H&E staining. (G) IHC staining of Ki67 (n = 3). (H to J) Immunoblot analysis of tumor-growth associated signaling pathways, histone acetylation marks, and PKM2. (K) Schematic illustration of SLC13A2-mediated metabolic and epigenetic regulation in tumor cells. OAA, oxaloacetate. The data are presented as means ± SEM. *P < 0.05; **P < 0.01, hSLC13A2-OE versus GFP group, two-tailed unpaired Student’s t test.