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Effects of COX inhibitors on (A) gastric ulcer healing and (B) angiogenesis in the ulcer bed. Oral treatment with celecoxib (10 mg/kg), flurbiprofen (5 mg/kg), HCT-1026 (6.5 mg/kg), or vehicle was started 3 days after ulcer induction and continued, once daily, for a week. Ulcer healing is expressed as a percent reduction in ulcer size from that on day 3 . *, P < 0.05; **, P < 0.01 (vs. the vehicle-treated group).
