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Effects of serum from rats treated with various COX inhibitors on (A) proliferation and (B) apoptosis of HUVEC in the absence and presence of an antibody against endostatin. HUVEC were incubated with serum from rats treated daily for 1 week with vehicle, celecoxib (10 mg/kg), flurbiprofen (5 mg/kg), or HCT-1026 (6.5 mg/kg). *, P < 0.05; **, P < 0.01 (vs. the vehicle-treated group). #, P < 0.05; ##, P < 0.01 (vs. corresponding group without antiendostatin).
