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Effects of COX inhibitors on platelet content of (A) endostatin and (B) VEGF. Rats were treated once daily for 7 days with vehicle (Veh), celecoxib (10 mg/kg), flurbiprofen (5 mg/kg), or HCT-1026 (6.5 mg/kg). Three hours after the final dose, washed platelets (2 × 108 per ml) were prepared and endostatin levels were determined in platelet lysates. *, P < 0.05; **, P < 0.01 (vs. the vehicle-treated group).
