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. 2002 Sep 13;99(20):13243–13247. doi: 10.1073/pnas.202392199

Figure 5.

Figure 5

Effects of COX inhibitors on basal and thrombin (1 unit/ml)-induced release of (A) endostatin and (B) VEGF from platelets. Rats were treated with vehicle, celecoxib (10 mg/kg), flurbiprofen (5 mg/kg), or HCT-1026 (6.5 mg/kg) once daily for 7 days. Three hours after the final dose, the platelets were harvested and challenged with saline or thrombin in a platelet aggregometer. Supernatants of the aggregates were collected and concentrations of endostatin and VEGF were measured by ELISA. *, P < 0.05; **, P < 0.01 (vs. vehicle-treated group). Ψ, P < 0.05 vs. the corresponding saline-treated group.