Table 1.
Baseline cardiovascular and pulmonary hemodynamic values in anesthetized eNOS+/+ and eNOS−/− mice
Hemodynamic value | Mice
|
|
---|---|---|
eNOS+/+ | eNOS−/−* | |
Mean systemic arterial pressure, mmHg | 85 ± 10 | 133 ± 12† |
Mean right atrial pressure, mmHg | 4.1 ± 0.5 | 4.2 ± 0.6 |
Heart rate, beats per min | 401 ± 14 | 409 ± 12 |
Cardiac output, ml/min | 10.6 ± 0.5 | 10.1 ± 0.5 |
Mean pulmonary arterial pressure, mmHg | 12.4 ± 1.0 | 19.2 ± 1.8† |
Mean pulmonary arterial wedge pressure, mmHg | 4.2 ± 0.7 | 4.6 ± 1.1 |
Total peripheral resistance, mmHg⋅ml−1⋅min | 8.1 ± 0.7 | 12.7 ± 1.0† |
Pulmonary vascular resistance, mmHg⋅ml−1⋅min | 0.77 ± 0.07 | 1.44 ± 0.1† |
n = 11 | n = 10 |
1 mm Hg = 133 Pa.
eNOS−/− mice were treated with vehicle.
P < 0.05 when compared with values in eNOS+/+ mice.