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. 2002 Sep 23;99(20):13260–13265. doi: 10.1073/pnas.192374899

Figure 2.

Figure 2

Comparison of GAF domains. Topology diagrams of YKG9 (a), PDE 2A GAF A (b), and GAF B (c). In GAF B, the helix α3, whose dipole interacts with the bound cGMP phosphate moiety, is indicated in blue. *, indicates 11 contacts to cGMP. Helix α4 in GAF B, which provides a large number of contacts, is indicated in orange. The conserved NKFDE motif of GAF A and B (see text) is indicated in green. In YKG9, the additional N-terminal helix is indicated in purple. Arrows indicate β-strands, and helices indicate α-helices.