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. 2002 Sep 23;99(20):13260–13265. doi: 10.1073/pnas.192374899

Figure 4.

Figure 4

Sequence alignment of GAF A and B domains from mouse PDE2A, human PDE2A, human PDE5A, and human PDE6A, -B, and -C. The secondary structure elements from PDE2A GAF A and B are indicated at the top line. Absolutely conserved residues are indicated in purple, and conserved residues are indicated in blue. Colored columns indicate the following contacts to cGMP: green, polar side chains; gray, hydrophobic side chains; pink, backbone amides. Yellow columns are residues in the NKFDE motif (see text). The 11 contact residues with cGMP are indicated with double underscored numbers 1–11. h, human; m, mouse; 2A, PDE2A; GA, GAF A; GB, GAF B.