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. 2002 Sep 16;99(20):13266–13271. doi: 10.1073/pnas.202296999

Figure 4.

Figure 4

LXA4 analogues inhibit LPS-induced oxidation of DHR 123 to rhodamine in human leukocytes. Blood samples were preincubated with vehicle or LXA4 analogues in the absence or presence of l-NAME (1 mM) as indicated, and then challenged with LPS at 37°C for 4 h. DHR 123 (20 μM) was added during the last 60 min of the incubation period. Intracellular rhodamine fluorescence is expressed as RFU. (A) Concentration-dependent effects of ATL1. (B) Comparison of the effects of LXA4 analogues (all at 500 nM) in the absence or presence of l-NAME. Values are means ± SEM (n = 5). *, P < 0.05; **, P < 0.01 (vs. LPS).