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The arousal response to episodic hypoxia is attenuated in β2 mutant mice. Either 20 min (A) or 50 min (B) of episodic hypoxia were administered; arousal from sleep was defined by movement (MVT) artifact (C). The arousal response from mutants (□) was consistently lower than from wild-type mice (■) to both stimuli (*, P = 0.015).
