Table 13.
Depression-like behavior: reported outcomes in METH and AMPH withdrawal studies.
| Reference | Withdrawal day(s) | Species/Strain | Drug | Test type | Results |
|---|---|---|---|---|---|
| Mouton et al. (2016) | 1 and 25 days | Flinders sensitive and Resistant line rats (♂) | METH | Forced Swim Test | ↓ immobility at PND35; ↑ immobility at PND60 |
| Avila et al. (2021) | 5–6 days | C57/Bl6 mice (♂♀) | METH | Tail Suspension Test | No change in immobility |
| Loxton and Canales (2017) | 15 days | Long Evans rats (♂) | METH | Open Field (Immobility measure) | ↑ Immobility |
| Mouton et al. (2016) | 1 and 25 days | Flinders sensitive and resistant line rats (♂) | METH | Social Interaction Test | ↓ Social interaction |
| Denning et al. (2024) | 24 h | C57BL/6J (B6J) mice | METH | Porsolt Forced-Swim Test | No change in immobility |
| Gao et al. (2025) | 48 h | C57BL/6 J mice | METH | Forced swim test | ↑ Immobility |
| Ismail et al. (2025) | 14 days | Albino mice | METH | Open field | ↑ Immobility |
| Ismail et al. (2025) | 14 days | Albino mice | METH | Forced swim test | ↓ Immobility |
| Ismail et al. (2025) | 14 days | Albino mice | METH | Social interaction test | ↑ Social interaction |