Table 1.

Measures of cough during cough induced hyperventilation (CHV) and isocapnic trials.

	CHV	Isocapnia
Measure	Mean ± SE	Mean ± SE	Δ (%)	Test	T/Z-score	p -value
Cough bout features
Cough Number	10.3 ± 1.0	11.8 ± 1.1	15	P	−2.22	0.048 *
Cough Frequency (Hz)	0.34 ± 0.04	0.38 ± 0.04	13	P	−1.98	0.074
Bout Duration (sec)	61.7 ± 2.3	61.4 ± 1.2	0	W	−0.72	0.470
Amplitudes (% max CIHV)
Diaphragm	73.7 ± 3.0	73.5 ± 3.5	0	P	0.09	0.933
Parasternal Left	79.7 ± 2.6	78.3 ± 3.1	−2	P	0.94	0.367
Parasternal Right	75.4 ± 3.3	75.8 ± 4.2	1	W	−0.34	0.733
Internal Oblique	75.6 ± 2.8	73.8 ± 3.4	−2	P	0.71	0.490
Amplitudes (cmH2O)
Average ESPR	48.1 ± 9.2	41.7 ± 9.2	−13	P	2.33	0.040 *
Maximum ESPR	64.3 ± 10.6	56.1 ± 9.8	−13	W	−3.03	0.002 ##
Phase durations (ms)
CTI	1019 ± 75	958 ± 59	−6	P	1.78	0.103
CTE1	433 ± 24	444 ± 21	3	P	−0.63	0.540
CTE2	1854 ± 363	1400 ± 254	−24	W	−0.88	0.380
CTTOT	3307 ± 385	2802 ± 288	−15	W	−1.19	0.233

ESPR, esophageal pressure; CT_I Cough inspiration; CT_E1 cough active expiration; CT_E2 cough passive expiration; CT_TOT total cough cycle time.

Paired t-test (P)

^{*** =}p < 0.001,

^{** =}p < 0.01,

^{* =}p < 0.05

Wilcoxon singed-rank test (W)

^{### =}p < 0.001,

^{## =}p < 0.01,

^{# =}p < 0.05

n = 12