Table 2.
Region |
R2
|
Age
|
Accuracy
|
RT
|
||||
---|---|---|---|---|---|---|---|---|
R2 | P | β ± SD | P | β ± SD | P | β ± SD | P | |
Cluster size | ||||||||
L PFC | 0.27 | 0.101 | 0.60 ± 0.25 | 0.029 | −0.07 ± 0.24 | 0.786 | −0.36 ± 0.22 | 0.118 |
R PFC | 0.56 | 0.001 | 0.76 ± 0.20 | 0.001 | 0.17 ± 0.19 | 0.540 | −0.30 ± 0.17 | 0.091 |
L PPC | 0.72 | 0.000 | 0.84 ± 0.16 | 0.000 | 0.11 ± 0.15 | 0.469 | −0.18 ± 0.14 | 0.192 |
R PPC | 0.69 | 0.000 | 0.77 ± 0.17 | 0.000 | 0.16 ± 0.16 | 0.328 | −0.13 ± 0.14 | 0.379 |
Peak t score | ||||||||
L PFC | 0.29 | 0.082 | 0.44 ± 0.25 | 0.091 | 0.11 ± 0.24 | 0.645 | −0.04 ± 0.22 | 0.852 |
R PFC | 0.53 | 0.002 | 0.75 ± 0.20 | 0.001 | −0.21 ± 0.19 | 0.278 | −0.15 ± 0.17 | 0.374 |
L PPC | 0.56 | 0.001 | 0.68 ± 0.20 | 0.003 | 0.03 ± 0.19 | 0.885 | −0.10 ± 0.17 | 0.574 |
R PPC | 0.50 | 0.004 | 0.54 ± 0.21 | 0.019 | 0.18 ± 0.20 | 0.391 | −0.10 ± 0.18 | 0.603 |
Multiple linear regression analyses was used to examine the relative contributions of age and task performance (accuracy and RT) to WM-related activation in the PFC and the PPC. Results of two separate analyses using two different measures: cluster size and peak t score in each activation cluster identified in Table 1. Analysis model R2, and corresponding P value, along with β weights, and their corresponding P values, are shown for each region. The analysis shows that in each of these regions, age is a significant predictor of brain activation, even after accounting for changes in task performance with age.