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. 2002 Sep 20;99(20):13336–13341. doi: 10.1073/pnas.162486399

Table 2.

Results of brain-behavior analyses using cluster size and peak t score

Region R2
Age
Accuracy
RT
R2 P β ± SD P β ± SD P β ± SD P
Cluster size
 L PFC 0.27 0.101 0.60  ± 0.25 0.029 −0.07  ± 0.24 0.786 −0.36  ± 0.22 0.118
 R PFC 0.56 0.001 0.76  ± 0.20 0.001 0.17  ± 0.19 0.540 −0.30  ± 0.17 0.091
 L PPC 0.72 0.000 0.84  ± 0.16 0.000 0.11  ± 0.15 0.469 −0.18  ± 0.14 0.192
 R PPC 0.69 0.000 0.77  ± 0.17 0.000 0.16  ± 0.16 0.328 −0.13  ± 0.14 0.379
Peak t score
 L PFC 0.29 0.082 0.44  ± 0.25 0.091 0.11  ± 0.24 0.645 −0.04  ± 0.22 0.852
 R PFC 0.53 0.002 0.75  ± 0.20 0.001 −0.21  ± 0.19 0.278 −0.15  ± 0.17 0.374
 L PPC 0.56 0.001 0.68  ± 0.20 0.003 0.03  ± 0.19 0.885 −0.10  ± 0.17 0.574
 R PPC 0.50 0.004 0.54  ± 0.21 0.019 0.18  ± 0.20 0.391 −0.10  ± 0.18 0.603

Multiple linear regression analyses was used to examine the relative contributions of age and task performance (accuracy and RT) to WM-related activation in the PFC and the PPC. Results of two separate analyses using two different measures: cluster size and peak t score in each activation cluster identified in Table 1. Analysis model R2, and corresponding P value, along with β weights, and their corresponding P values, are shown for each region. The analysis shows that in each of these regions, age is a significant predictor of brain activation, even after accounting for changes in task performance with age.